What is ketamine?

Ketamine is a transformational medicine of the mind. It can rapidly —often within an hour or two— lift the symptoms of anxiety, depression, and other conditions.

A Trusted and Widely-Used Medicine

Ketamine was approved by the FDA in 1970 as an anesthetic and analgesic, and has been listed on the World Health Organization's List of Essential Medicines since 1985.

Ketamine is also prescribed off-label to treat a wide range of mental health issues.

Safety information
Important FDA Safety Information

Ketamine is not FDA-approved for the treatment of depression or anxiety. Learn more about off-label uses here.

Side effects of ketamine treatment may include: altered sense of time, anxiety, blurred vision, diminished ability to see/hear/feel, dry mouth, elevated blood pressure or heart rate, elevated intraocular or intracranial pressure, excitability, loss of appetite, mental confusion, nausea/vomiting, nystagmus (rapid eye movements), restlessness, slurred speech, synesthesia (a mingling of the senses).

Do not proceed with ketamine treatment if any of the following apply to you:

  • Allergic to ketamine
  • Symptoms of psychosis or mania
  • Uncontrolled high blood pressure
  • CHF or other serious heart problem
  • Severe breathing problem
  • History of elevated intraocular or intracranial pressure
  • History of hyperthyroidism
  • Other serious medical illness
  • Pregnant, nursing, or trying to become pregnant

Ketamine has been reported to produce issues including, but not limited to, those listed below. However, lasting adverse side-effects are rare when medical protocols are carefully followed.

While ketamine has not been shown to be physically addictive, it has been shown to cause moderate psychological dependency in some recreational users.

  • In rare cases, frequent, heavy users have reported increased frequency of urination, urinary incontinence, pain urinating, passing blood in the urine, or reduced bladder size
  • Ketamine may worsen problems in people with schizophrenia, severe personality disorders, or other serious mental disorders.
  • Users with a personal or family history of psychosis should be cautious using any psychoactive substance, including ketamine, and discuss potential risks with your MindBloom® clinician before proceeding with treatment.
  • The dissociative effects of ketamine may increase patient vulnerability and the risk of accidents.

To promote positive outcomes and ensure safety, follow these ketamine treatment guidelines:

  • Do not operate a vehicle (e.g., car, motorcycle, bicycle) or heavy machinery following treatment until you’ve had a full night of sleep
  • Refrain from taking benzodiazepines or stimulants for 24 hours prior to treatment
  • Continue to take antihypertensive medication as prescribed
  • Avoid hangovers or alcohol intake
  • Refrain from consuming solid foods within 3 hours prior to treatment and liquids within 1 hour prior to treatment
  • Ketamine treatment should never be conducted without a monitor present to ensure your safety

A Promising Treatment for Mental Health

Known for its anesthetic effects and therapeutic potential, ketamine is increasingly being used as a treatment for anxiety and depression.

At lower doses, ketamine can disrupt negative feelings and preoccupations and help the brain create new, healthier patterns.

How Does it Work?

Ketamine acts on the brain to provide relief from anxiety and depression.

Fuel Neural Growth

When people suffer from chronic anxiety and depression, their neurons become stunted with fewer connections.

Ketamine helps repair this damage by stimulating neuroplasticity and fertilizing the brain, restoring and strengthening new connections between neurons.

Reduce Negative Thoughts

Ketamine can also offer relief from negative thoughts by normalizing activity in a part of the brain known as the default mode network.

By altering connectivity in this part of the brain, ketamine can help people to break out of old thought patterns that cause anxiety and depression.

A Powerful Medicine

With its ability to promote the creation of new, healthy neural connections, ketamine can be a powerful tool for managing mental health.

For many people, the effects of ketamine therapy can last for months, with intermittent "boosters" extending the effects even further.

Gentle Onset Tablets

While intravenous and intramuscular administration methods can be abrupt, Mindbloom provides tablets that are dissolved under the tongue and gently take effect over 10-15 minutes.

Intravenous
Intramuscular
Sublingual

Feelings of Relief

By temporarily silencing negative thoughts, ketamine therapy can offer much needed relief and healing.

“Ketamine silenced the constant thoughts that have been torturing me for most of my life.”

Jeff, IT Business Owner

“Since using Mindbloom, I’ve experienced relief from my depression and anxiety.”

Amanda, Administrative Assistant

“My experience culminated in the notion that everything is going to be okay.”

Dan, IT Project Manager

Gentle Experience

While everyone’s experience is different, many clients describe their Mindbloom sessions as gentle.

“The most surprising part of my Mindbloom experience was how gentle and safe it felt.”

Brenna, Writer

“I expected a punch in the face, but it felt more like a tickle on the arm.”

Brittni, Project Manager

“I appreciate the comfort and safety of my own living room.”

Noah, Land Use Consultant

New Perspective

Ketamine therapy facilitates new perspectives that can help us better process and move on from pain.

“Mindbloom gave me a better perspective on anxiety, depression, and life itself.”

Deborah, Student

“I’ve reframed my negative thoughts into positive ones.”

Sarah

“Mindbloom helped build a foundation that I needed to keep me from spiraling and feeling lost.”

Andrew, Financial Advisor
Science Research

Ketamine Research

Clinical research continues to demonstrate that ketamine can be used to treat mental health conditions and their symptoms successfully.

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Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review

A study of ketamine's psychotherapeutic potential and systematic review of the extant evidence on ketamine's effects in treating mental health disorders.

Miscellaneous

Landmark Study of Ketamine Therapy

At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial

Anxiety

Understanding How Ketamine Brings About Rapid Improvement in OCD

Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to build on our discovery that a potent NMDA receptor antagonist, ketamine, has rapid (in hours) and robust therapeutic effects in OCD. The proposed projects test the acute mechanism of action of ketamine at the level of molecules, circuits, and network synchrony to determine how NMDA receptor antagonism modifies the underlying pathology of OCD to relieve repetitive thoughts and behaviors.

Obsessive-Compulsive Disorder